Model Barrier Affecting Drug Transport

Signaled drug delivery and transport across the blood-brain barrier.

We use a mathematical model to describe the delivery of a drug to a specific region of the brain. The drug is carried by liposomes that can release their cargo by application of focused ultrasound (US). Thereupon, the drug is absorbed through the endothelial cells that line the brain capillaries and form the physiologically important blood-brain barrier (BBB). We present a compartmental model o...

Drug Transport and Metabolism in the Blood–Brain Barrier

Despite recent advances, the treatment of brain diseases and neurological disorders, such as the Parkinson and Alzheimer syndromes, multiple sclerosis, brain cancer, psychiatric disorders, many forms of epilepsy, chronic pain, and migraine, remains a major challenge. There is a growing need for the development of effective CNS-active drugs that are able to reach the desired regions of the brain...

Factors Affecting Drug Absorption

Investigating the Factors Affecting Drug-drug Interactions

A drug-drug interaction (DDI) is a change in the effect of a drug when administered with another drug or group of drugs. Drug interactions are common and cause increased hospital admission rates, treatment failure, avoidable medical complications, and even deaths. A literature survey is conducted to find factors affecting drug-drug interactions in cohorts that are more likely to be affected by ...

Drug properties affecting aerosol behavior.

The widespread use of aerosol therapy in the treatment of pulmonary diseases is based on optimizing drug properties and aerodynamic behavior of airborne particulates. In order to understand drug properties and aerodynamic behavior, it is important to recognize that each category of inhaler delivers a product with different physicochemical characteristics, and that these properties determine the...